The function of retinal pericytes in wet AMD

Dr Mihaela Crisan - University of Edinburgh - £25,000

This research project is investigating how abnormal blood vessel growth contributes to wet age-related macular degeneration (AMD). By studying candidate protein activity, the research aims to identify potential new ways to protect the retina and preserve vision.

What is the problem?

Retinal pericytes are specialised cells that wrap around tiny blood vessels (capillaries) in the retina. They help stabilise the capillaries, regulate blood flow, maintain the blood-retina barrier (BRB), and support overall vascular health. In wet AMD, abnormal growth of blood vessels can lead to retinal damage and vision loss.

What are they doing?

This project aims to find out more about the development of wet AMD by looking at candidate protein activity normally found in the pericytes of blood vessels during development but not in healthy adult tissues.  

It is known that injury and diseases such as cancer see a resurgence of activity of certain candidate proteins which play a key role in driving abnormal blood vessel growth. This is also true when the retina is damaged. This research will look into the possibility that specific candidate proteins promote the vascularisation (increase in blood vessels) seen in wet AMD. 

How can this help?

Understanding the metabolism of these candidate proteins in AMD could reveal whether a drug that blocks this protein might prevent or reduce retinal damage, helping to preserve vision for people affected by the condition.