The function of retinal pericytes in wet AMD

Dr Mihaela Crisan - University of Edinburgh - £25,000

This research project is investigating how abnormal blood vessel growth contributes to wet age-related macular degeneration (AMD). By studying a protein called CD248, the research aims to identify potential new ways to protect the retina and preserve vision.

What is the problem?

Retinal pericytes are specialised cells that wrap around tiny blood vessels (capillaries) in the retina. They help stabilise the capillaries, regulate blood flow, maintain the blood-retina barrier (BRB), and support overall vascular health. In wet AMD, abnormal growth of blood vessels can lead to retinal damage and vision loss.

What are they doing?

This project will explore the role of CD248, a protein normally active during blood vessel development but inactive in healthy adult tissues. CD248 is known to reactivate after injury and in diseases such as cancer, where it drives abnormal blood vessel growth. The researchers will investigate whether CD248 plays a similar role in the retina in AMD.

How can this help?

Understanding the role of CD248 in AMD could reveal whether a drug that blocks this protein might prevent or reduce retinal damage, helping to preserve vision for people affected by the condition.